While I doubt the writers will go for a clean-the-slate ending, it wouldn't surprise me if we didn't get some "looping" in the next two seasons. For instance, I fully expect one of the characters (probaby Locke) to attempt to turn the clock back so that certain aspects of the ordeal did not happen.

There's been a lot of this already, with scenes from Seasons 1 and 2 being replayed in the latter parts of 3 and 4 from the POV of different characters who were originally not introduced.

I think this will be one of the things the writers lean on going forward, perhaps even to the extent where they replace the flashbacks and flash forward effects we've seen in the past.

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