Locke also played Elisha Cuthbert's dad/Luke Wilson's boss on Old School.
Jack was obviously in Party of Five.
Evangeline Lilly did this hilarious singles' hotline ad right before Lost started. They actually showed her commercials during the first season.
Daniel Dae Kim was some sniveling, rotten lawyer for Wolfram and Hart on Angel.
I remember Emilie de Ravin from Brick (not an acronym).
Michael was Link on Matrix: Reloaded and Matrix: Revolutions.
Juliet was Frank's wife in Frequency, which is a strange coincidence because that movie had weird phenomena in it, like radio signals that traveled through time.
Charlie was obviously Meri in LOTR.
Ana-Lucia has been in...well, in a lot of stuff actually. My go-to is The Fast and the Furious...bleh.
Mr. Eko was some drug-addled ******* of an inmate on Oz.
Tom was the pilot (Swamp Thing) on Con-Air.
Daniel Faraday was Maggie Gyllenhal's pussy of a boyfriend on Secretary.
Miles was the bad guy in Rush Hour.
Christian was Joker's commanding officer when he was stationed in Ho Chin Minh City in Full Metal Jacket.
Naomi was the inexplicable black princess in the middle of Europe set opposite of Martin Lawrence in the horrible movie Black Knight (I had the unfortunate circumstance of watching it on a plane).
Richard played the suave Cuban photographer on Suddenly Susan.
Danny Pickett (the ******* who wants to kill Sawyer when he's imprisoned at the Hydra station) also plays another ******* on "Kill Bill Vol. 1" as Buck ("My name is Buck, and I'm here to ****.")
Charles Widmore, funny enough, is actually on Ugly Betty (another ABC show) as well as Lost concurrently!
Jack's ex-wife, Sarah, played sexy PR lady, Virginia Venit, on Happy Gilmore. Plus, she does some fake tan lotion commercials that I remember.
In all irony, Doc Arzt plays a detective on Final Destination who's skeptical of the course-correction of fate when someone escapes death (the entire point of the movie).
Ethan also played some Euro-trash looking henchman for John Travolta in Swordfish.
Penny is Sarah Connor's ex-fiancee's wife on Terminator: The Sarah Connor Chronicles, also running concurrently with Lost.
Minkowski was the dorky Indian scientist in Short Circuit. I found that especially hilarious when I first made the connection.
Cassidy is Aaron Eckhart's ex-wife in Thank You for Smoking.
Inman was the ******* chief guard in The Shawshank Redemption
Katey Segal, Locke's former flame, is obviously of Married...with Children and Futurama fame.
Ana-Lucia's mom, was the guard that got tied up and almost raped by one of the inmates in Con-Air.


I think that's all I can remember right now. BTW, this is my favorite game when watching movies or shows, so it's cool that someone else initiated this!

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Abaddon