Well, we know that Smokie judges people (remember it asking Eko to repent for his sins in the guise of his brother), and if it decides you are unworthy...

We also know that it leaves certain people alone. Remember the scene when Juliette and Kate were handcuffed together in the stand of trees, and it seemed to take pictures of Juliette then leave.

It seems to have an agenda--killing off people it thinks are bad, and protecting (or ignoring) the good ones.

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"Jesus Christ...is not a weapon"